Three-dimensional stromal cell and tissue culture system
US5478739A · kind A · utility
217Cited by
10References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 23, 1992 |
| Grant date | Dec 26, 1995 |
| Priority date | — |
| Expiry date | Oct 23, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S623/915
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to an improved three-dimensional cell culture system in which cells are grown on a three-dimensional matrix while cycling the cultures between metabolically favorable and metabolically unfavorable (but noncytotoxic) conditions. The invention is based, at least in part, on the discovery that cycling the cultures in this manner optimizes the formation of extracellular matrix and produces an overall structure that more closely resembles naturally occurring tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.