Peptide amides, processes for the preparation thereof and agents containing these as fibrin/thrombin clotting inhibitors

US5478810A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Werner Stuber · Lahntal, DE
• Karl Fickenscher · Marburg, DE

Key dates

• Filing date: Feb 24, 1993
• Grant date: Dec 26, 1995
• Expiry date: Feb 24, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptide amides of the formula I (SEQ ID NOS: 3-21) EQU GPRP--X--NR.sub.1 --R.sub.2 I where G is the amino acid glycine, P is the amino acid L-proline, R is the amino acid L-arginine, X is a proteinogenous amino acid apart from proline or a dipeptide from these amino acids including proline, N is nitrogen and R.sub.1 and R.sub.2 are identical or different and are hydrogen or a lower alkyl chain having up to 4 carbon atoms; processes for the preparation thereof and the use thereof as medicament or for diagnostic purposes are described.