4-amino(alkyl)cyclohexane-1-carboxamide compound and use thereof
US5478838A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 7, 1994 |
| Grant date | Dec 26, 1995 |
| Priority date | — |
| Expiry date | Mar 7, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
4-Amino(alkyl)cyclohexane-1-carboxamide compounds of the formula (I) ##STR1## wherein each symbol is as defined in the Specification, isomers thereof and pharmaceutically acceptable acid addition salts thereof. The 4-amino(alkyl)cyclohexane-1-carboxamide compounds, isomers thereof and pharmaceutically acceptable acid addition salts thereof of the present invention have potent and long-lasting coronary, cerebral, renal and peripheral blood flow increasing actions and are less toxic, and thus are useful as a potent and long-lasting antihypertensive agent and an agent for the prevention and treatment of diseases in the circulatory organs such as coronary, cerebral, renal and peripheral arteries. Moreover, the compounds of the present invention exhibit inhibitory action on experimental asthma of guinea pigs, which is caused by histamine inhalation, and inhibitory action on contraction of trachea strips isolated from guinea pigs, which is caused by acetylcholine, and thus are useful as therapeutic agents for asthma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.