Ether derivatives having 5-lipoxygenase inhibitory activity
US5478842A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Apr 28, 1994 |
| Grant date | Dec 26, 1995 |
| Priority date | — |
| Expiry date | Apr 28, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns ether derivatives of the formula I EQU Q.sup.1 --X--Ar--Q.sup.2 I wherein PA1 Q.sup.1 is an optionally substituted 9-, 10- or 11-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur; PA1 X is oxy, thio, sulphinyl or sulphonyl; PA1 Ar is optionally substituted phenylene, pyridinediyl, pyrimidinediyl, thiophenediyl, furandiyl, thiazolediyl, oxazoiediyl, thiadiazoiediyl or oxadiazolediyl; and PA1 Q.sup.2 is selected from the groups of the formulae II and III: ##STR1## wherein R.sup.1 is hydrogen, (2-5C)alkanoyl or optionally substituted benzoyl; PA2 R.sup.2 is (1-4C)alkyl; and PA2 R.sup.3 is hydrogen or (1-4C)alkyl; PA2 or R.sup.2 and R.sup.3 are linked to form a methylene, vinylene, ethylene or trimethylene group; PA1 or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.