Displacement chromatography of proteins using low molecular weight displacers
US5478924A · kind A · utility
13Cited by
5References
14Claims
0Family size
Inventors
Key dates
| Filing date | Feb 16, 1994 |
| Grant date | Dec 26, 1995 |
| Priority date | — |
| Expiry date | Feb 16, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/02
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A method for the purification of proteins by displacement chromatography on ion exchange media using low molecular weight displacers is disclosed. Several classes of low molecular weight, charged species are exemplified, including aminoacids, peptides, antibiotics and dendrimeric polymers. Novel compounds useful as displacers are dendrimers of formula ##STR1## wherein R.sup.1 is lower alkyl, n is 2 to 6, and X is a common counter anion and similar dendritic polymers based thereon.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.