Synthetic immunoreglators, and methods of use and preparation
US5480642A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 21, 1988 |
| Grant date | Jan 2, 1996 |
| Priority date | — |
| Expiry date | Jul 21, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/57
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
To regulate the immune response to an antigen, a subject with the antigen is injected with polyanionic polysaccharide derivative: (1) having a molecular weight of between 1,000 and 600,000; (2) selected to correspond to the antigen; (3) not being cytotoxic at an effective dosage; and (4) stimulating a cell-mediated immune response. For virus, as an example, mycodextran sulfate or pustulan sulfate may be used in sufficient quantities to stimulate cell-mediated immune responses without stimulating synthesis of gamma-E globulin and gamma-G globulins. The polyanionic polysaccharide derivative may be injected alone to stimulate cell-mediated immune responses to antigens in a diseased subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.