Effervescent pharmaceutical composition containing ibuprofen and its method of preparation
US5480652A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 8, 1993 |
| Grant date | Jan 2, 1996 |
| Priority date | — |
| Expiry date | Feb 8, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a novel pharmaceutical composition for the preparation of effervescent powders or tablets incorporating ibuprofen or one of its pharmaceutically acceptable salts as the active ingredient. This composition comprises: an effective amount of ibuprofen or one of its pharmaceutically acceptable salts; a pharmaceutically acceptable effervescent system comprising at least one alkaline carbonate and at least one organic acid, preferably in a sufficient amount to give a pH below about 8; and at least one pharmaceutically acceptable antioxidant in a sufficient amount to stabilize the ibuprofen. This composition has a remarkable stability both in powder form and in tablet form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.