Process for the biotechnological preparation of l-thienylalanines in enantiomerically pure form from 2-hydroxy-3-thienylacrylic acids, and their use

US5480786A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Gerhard Kretzschmar · Eschborn, DE
• Johannes Meiwes · Idstein, DE
• Manfred Schudok · Eppstein, DE
• Peter Hammann · Kelkheim, DE
• Ulrich Lerch
• Susanne Grabley · Königstein, DE

Key dates

• Filing date: Jul 29, 1993
• Grant date: Jan 2, 1996
• Expiry date: Jul 29, 2013

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/898
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

L-Thienylalanines are prepared via the hydantoin or the azlactone route. The starting substances used for the biotransformation are 2-hydroxy-3-thienylacrylic acids. The innovative step consists in the transamination of the enol form of the 2-hydroxy-3-thienylacrylic acids to give L-thienylalanines with the aid of biotransformation. The transaminiation is carried out in the presence of L-aspartic acid or L-glutamic acid as amino donor.