Anti-inflammatory peptide analogs and treatment to inhibit vascular leakage in injured tissues
US5480869A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 23, 1993 |
| Grant date | Jan 2, 1996 |
| Priority date | — |
| Expiry date | Jul 23, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Small, anti-inflammatory compounds that are peptide analogs are described useful to inhibit inflammation of a mammal's skin, mucous membranes, or lacerations of the musculature or injury to the brain or leakage of fluids into the air spaces of the lungs. Peptide analogs of the invention have the primary sequence T.sub.N -A.sub.1 -A.sub.2 -A.sub.3 -A.sub.4 -A.sub.5 -A.sub.6 -T.sub.C where one of the moieties is in the D-configuration. A.sub.1 and A.sub.2 are each a basic polar amino acids while each of A.sub.3, A.sub.4, and A.sub.6 is a hydrophobic amino acid. A.sub.5 can be a variety of structures and appears to function to optimize the spatial relationship between the hydrophobic and the basic residues. T.sub.N is selected or modified to convey resistance against enzymatic degradation. T.sub.C is an amino group or an amidated amino acid, preferably hydrophobic.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.