Benzoxazinone and benzothiazinone derivatives having cardiovascular activity

US5480882A · kind A · utility

Assignee

• ITALFARMACO SPA · IT

Inventors

• Alberto Sala · Monza, IT
• Roberto Barani · Cascina Uboldi, IT
• Francesca Benedini · Milano, IT
• Giorgio Bertolini · Sesto San Giovanni, IT
• Giancarlo Dona · Milano, IT
• Gianni Gromo · Sesto San Giovanni, IT
• Silvio Levi · Milano, IT

Key dates

• Filing date: Nov 23, 1994
• Grant date: Jan 2, 1996
• Expiry date: Nov 23, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D279/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## wherein R represents hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.7 cycloalkyl, methylene-dioxy or phenyl, which may be substituted by one or two groups independently selected from hydroxy, halogen, nitro, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy; R.sub.1 and R.sub.2 independently represent hydrogen, COOR.sub.3, --CONR.sub.4 R.sub.5, ##STR2## --OCONR.sub.4 R.sub.5, --OCOR.sub.3, --NR.sub.4 R.sub.5, --OCOOR.sub.6, --NR.sub.3 COR.sub.7, --NR.sub.CONR.sub.4 R.sub.5, --N.dbd.CH--NR.sub.4 R.sub.5, NO.sub.2, CN, OH, SR.sub.3, wherein R.sub.3 is hydrogen or C.sub.1 -C.sub.6 alkyl, R.sub.4 and R.sub.5 independently are hydrogen or C.sub.1 -C.sub.6 alkyl, R.sub.6 is C.sub.1 -C.sub.6 alkyl, and R.sub.7 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy, with the proviso that R.sub.1 and R.sub.2 cannot be hydrogen at the same time; X is oxygen or sulphur; Y represents a C.sub.2 -C.sub.6 alkylene chain or a C.sub.5 -C.sub.7 cycloalkylene group; and their pharmaceutically acceptable salts are provided and their use in pharmaceutical compositions which may be used in the treatment of cardiovascular diseases.