Antagonists of LHRH

US5480969A · kind A · utility

Assignees

• The Administrators of the Tulane Educational Fund · US
• The Board of Regents of the University of Texas System · US

Inventors

• Cyril Y. Bowers · New Orleans, US
• Karl Folkers · Austin, US
• Anders Ljungqvist · Austin, US
• Dong-Mei Feng · Harleysville, US
• Anna Janceka · Austin, US

Key dates

• Filing date: Sep 15, 1992
• Grant date: Jan 2, 1996
• Expiry date: Sep 15, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

LHRH antagonists similar to antide and congeners with higher water solubility have been synthesized by substitutions in positions 1, 5 or 6 with hydrophilic residues. These peptides have antiovulatory activity with minimal histamine releasing effect.