Process for preparing N-protected amino acid .alpha.-halomethyl ketones and alcohols from N-protected amino acid esters
US5481011A · kind A · utility
23Cited by
0References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 13, 1994 |
| Grant date | Jan 2, 1996 |
| Priority date | — |
| Expiry date | Dec 13, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C271/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a novel method useful for the conversion of amino acids to halomethylketones, which are then converted to amino acid epoxides. Such epoxides are important intermediates for the synthesis of inhibitors of renin and HIV protease, which are particularly useful in the treatment and/or prevention of HIV infection (AIDS).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.