Phenone compounds, manufacturing method and pharmaceutical preparations containing them

US5481043A · kind A · utility

Assignee

• Plantamed Arzneimittel GmbH · DE

Inventors

• Hildebert Wagner · Breitbrunn am Chiemsee, DE
• Walter Dorsch · Hersbruck, DE
• Hermann Stuppner · Götzens, AT
• Sandor Antus · Budapest, HU

Key dates

• Filing date: Feb 18, 1992
• Grant date: Jan 2, 1996
• Expiry date: Feb 18, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/203
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain new phenone derivatives of the formula (I) ##STR1## in which R.sup.1 =CH.sub.3, PA0 R.sup.2 =H, Cl, Br, I, methyl, hydroxy, methoxy, propoxy, propoxy or ethoxy; PA0 R.sup.3 =H or .beta.-D-glykosyl; PA0 R.sup.4 =H, Cl, Br, I, methyl, hydroxy, methoxy, propoxy, iso-propoxy or ethoxy; PA0 R.sup.5 =H or hydroxy, and the pharmaceutically acceptable salts, ethers and esters thereof, with the exception of the compounds 4-hydroxyacetophenone, 4-hydroxy-3-methoxy-acetophenone, 4-glucopyranosyloxy-acetophenone, 4-glucopyranosyloxy-3-methoxyacetophenone, 4-galactopyranosyloxy-3-methoxy-acetophenone, 4-glucopyranosyloxy-3,5-dimethoxy-acetophenone and galactopyranosyloxy-3,5-dimethoxy-acetophenone and a method for manufacturing them and pharmaceutical preparations containing them. The invention also concerns pharmaceutical preparations containing at least one compound of the formula (II) ##STR2## in which R.sup.1 denotes H, OH, alkoxy or C.sub.1-8 alkyl; PA0 R.sup.2 denotes H or C.sub.1-4 alkoxy; PA0 R.sup.3 denotes OH or a .beta.-D/alpha-L-glykosyl group (di-or- triglykosyl) which is substituted optionally by low molecular C.sub.1-4 aliphatic or aromatic acids, PA0 R.sup.4 denotes H or…