Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast

US5482700A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Julius Deutsch · Chicago, US
• Heinz Gries · Berlin, DE
• Erich Klieger · Berlin, DE
• Ulrich Niedballa · Berlin, DE
• Franz-Josef Renneke · Bergkamen, DE
• Juergen Conrad · Marburg, DE
• Wolfgang Muetzel · Berlin, DE

Key dates

• Filing date: Jul 1, 1994
• Grant date: Jan 9, 1996
• Expiry date: Jul 1, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

1. Compounds of general Formula I ##STR1## wherein n and m in each case mean the numbers 0, 1, 2, 3 and 4, PA1 X stands for a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-39, 42-44, 49 or 57-83, PA1 R.sup.1 and R.sup.2, being different, mean in each case a hydrogen atom or a straight-chain, branched, saturated or unsaturated C.sub.0 -C.sub.20 -alkylene group which optionally contains imino, phenylenoxy, phenylenimino, amido, hydrazido, ester group(s), oxygen, sulfur and/or nitrogen atom(s) and is substituted, if desired, by hydroxy, mercapto, imino, epoxy, oxo, thioxo and/or amino group(s), this alkylene group exhibiting at the end either a second molecule of general Formula I.sub.A or I.sub.B ##STR2## a functional group, or, linked by way of this functional group, a bio- or macromolecule, are valuable diagnostic and therapeutic media.