Stabilized pharmaceutical peptide compositions

US5482931A · kind A · utility

Assignee

• Ferring AB · SE

Inventors

• Alan Harris · Malmö, SE
• Birgitta Tennhammar-Ekman · Malmö, SE

Key dates

• Filing date: Jun 29, 1993
• Grant date: Jan 9, 1996
• Expiry date: Jun 29, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/095
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a stabilized aqueous composition for administration to a patient comprising a biologically active peptide, a buffer, a quaternary amine-type preservative or disinfectant, and an osmotic pressure-controlling agent, which composition can be stored and used at room temperature. The buffer stabilizes the pH of the composition between about 4 and 6. The preferred buffer contains citrate and/or phosphate, and the preferred preservative or disinfectant is benzalkonium chloride. The composition protects the peptide contained therein from adhering to container surfaces, particularly in containers made of polymeric materials.