Quinazolinone antianginal agents
US5482941A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 6, 1994 |
| Grant date | Jan 9, 1996 |
| Priority date | — |
| Expiry date | May 6, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of formula: ##STR1## and pharmaceutically acceptable salts thereof wherein PA1 R.sup.1 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or CONR.sup.5 R.sup.6 ; PA1 R.sup.2 is H or- C.sub.1 -C.sub.4 alkyl; PA1 R.sup.3 is C.sub.2 -C.sub.4 alkyl; PA1 R.sup.4 is H, C.sub.2 -C.sub.4 alkanoyl optionally substituted with NR.sup.7 R.sup.8, (hydroxy)C.sub.2 -C.sub.4 alkyl optionally substituted with NR.sup.7 R.sup.8, CH.dbd.CHCO.sub.2 R.sup.9, CH.dbd.CHCONR.sup.7 R.sup.8, CH.sub.2 CH.sub.2 CO.sub.2 R.sup.9, CH.sub.2 CH.sub.2 CONR.sup.7 R.sup.8, SO.sub.2 NR.sup.7 R.sup.8, SO.sub.2 NH(CH.sub.2).sub.n NR.sup.7 R.sup.8 or imidazolyl; PA1 R.sup.5 and R.sup.6 are each independently H or C.sub.1 -C.sub.4 alkyl; PA1 R.sup.7 and R.sup.8 are each independently H or C.sub.1 -C.sub.4 alkyl, or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, morpholino or 4-(NR.sup.10)-1-piperazinyl group wherein any of said groups is optionally substituted with CONR.sup.5 R.sup.6 ; PA1 R.sup.9 is H or C.sub.1 -C.sub.4 alkyl; PA1 R.sup.10 is H, C.sub.1 -C.sub.3 alkyl or (hydroxy)C.sub.2 -C.sub.3 alkyl; and PA1 n is 2, 3 or 4; with the proviso that R.sup.4 is not …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.