2,4-and 2,5-bistetrazolylpyridines and the use thereof as pharmaceuticals

US5482953A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Gerrit Schubert · Kelkheim, DE
• Ekkehard Baader · Königstein, DE
• Martin Bickel · Frankfurt am Main, DE
• Volkmar Gunzler-Pukall · Marburg, DE

Key dates

• Filing date: Jan 21, 1994
• Grant date: Jan 9, 1996
• Expiry date: Jan 21, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 2,4- and 2,5-bistetrazolylpyridines. Said compounds inhibit the enzymes proline hydroxylase and lysine hydroxylase and bring about a selective inhibition of collagen biosynthesis. They are used as fibrosuppressants and immunosuppressants.