Naphthyl compounds, intermediates, processes, compositions, and method of inhibiting restenosis

US5484795A · kind A · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Henry U. Bryant · Indianapolis, US
• George J. Cullinan · Trafalgar, US
• Jeffrey A. Dodge · Indianapolis, US
• Kennan J. Fahey · Indianapolis, US
• Charles D. Jones · Indianapolis, US
• Charles Willis Lugar, III · McCordsville, US
• Brian S. Muehl · Indianapolis, US

Key dates

• Filing date: Apr 21, 1995
• Grant date: Jan 16, 1996
• Expiry date: Apr 21, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a compound of formula I ##STR1## wherein R.sup.1 is --H, --OH, --O(C.sub.1 -C.sub.4 alkyl), --OCOC.sub.6 H.sub.5, --OCO(C.sub.1 -C.sub.6 alkyl), or --OSO.sub.2 (C.sub.4 -C.sub.6 alkyl); PA1 R.sup.2 is --H, --OH, --O(C.sub.1 -C.sub.4 alkyl), --OCOC.sub.6 H.sub.5, --OCO(C.sub.1 -C.sub.6 alkyl) or --OSO.sub.2 (C.sub.4 -C.sub.6 alkyl); PA1 n is 2 or 3; and PA1 R.sup.3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt thereof, for treating restenosis.