Tri-aza macrocycles and metal complexes thereof
US5484893A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 21, 1993 |
| Grant date | Jan 16, 1996 |
| Priority date | — |
| Expiry date | Jun 21, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D255/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Ti-aza macrocycles of formula (1), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, is each a hydrogen atom or an alkyl, alkoxyalkyl, --CO.sub.2 H, --SO.sub.3 H, PO.sub.3 H.sub.2 or aryl group; L is a covalent bond or linker group; Z is a hydrogen atom or a reactive functional group, with the proviso that when L is a covalent bond Z is a reactive functional group; and metal complexes and/or salts thereof are described together with processes for their preparation and compositions containing them. The compounds are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours, and are particularly suitable for coupling to other molecules such as proteins for use in diagnosis and therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.