Process for preparing benzo[b]naphthyridines
US5484921A · kind A · utility
1Cited by
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2Claims
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Assignee
Inventors
Key dates
| Filing date | Apr 8, 1994 |
| Grant date | Jan 16, 1996 |
| Priority date | — |
| Expiry date | Apr 8, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a method for the preparation of benzo[b]naphthyridines having the general formula (I) ##STR1## comprising: 1) condensation of an amine having the formula R'--NH--CH.sub.2 --CH.sub.2 --R" with a chlorofluoroquinoline of formula (II) ##STR2## 2) cyclization of the obtained fluoroquinoline of formula (IV) ##STR3## and; 3) oxidation of tetrahydro-1,2,3,4benzo[b]naphthyridine-1,8 of formula (V) ##STR4## is effected, and then, optionally, the ester obtained is transformed into an acid and optionally into a salt.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.