Method and system for measurement of mechanical properties of molecules and cells
US5486457A · kind A · utility
33Cited by
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21Claims
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Key dates
| Filing date | Aug 25, 1993 |
| Grant date | Jan 23, 1996 |
| Priority date | — |
| Expiry date | Aug 25, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/808
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Mechanical stresses and deformations are applied directly to cell surface receptors or molecules and measured using a system including a magnetic twisting device in combination with ferromagnetic microbeads coated with ligands for integrins or any other surface receptors. The system can be used diagnostically to characterize cells and molecules and to determine the effect of transformation and compounds, including drugs, on the cells and molecules. The system can also be used to induce cells to grow or alter production of molecules by the cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.