Histamine H.sub.3 -receptor antagonists and therapeutic uses thereof
US5486526A · kind A · utility
6Cited by
7References
9Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Oct 29, 1993 |
| Grant date | Jan 23, 1996 |
| Priority date | — |
| Expiry date | Oct 29, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to compounds of the class of piperidyl-imidazole derivative histamine H.sub.3 -receptor antagonists. Such compounds have affinity for histamine H.sub.3 -receptor, and preferably penetrate the blood-brain barrier. The compounds can block the soporific effect of an H.sub.3 -receptor agonist. Illustrative of the compounds of the invention is the molecule 4-(1-cyclohexylvaleroyl-4-piperidyl)-1H-imidazole. These compounds have been found to have utility in treating cognitive disorders and have been found to be useful as appetite suppressants.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.