Tetrapeptide derivatives and analogues
US5486597A · kind A · utility
3Cited by
0References
24Claims
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Assignee
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Key dates
| Filing date | Jun 17, 1993 |
| Grant date | Jan 23, 1996 |
| Priority date | — |
| Expiry date | Jun 17, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/595
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The C-terminal tetrapeptide of gastrin, Trp-Met-Asp-Phe-NH.sub.2, possesses gastrin pharmacological activity. Replacement of the methionyl moiety in the gastrin tetrapeptide, or its analogs, with a naphthylalanyl group produces compounds which interact with gastrin and/or cholecystokinin receptors, but have reduced gastrin and/or cholecystokinin agonist activity. Such partial agonists or antagonists of gastrin and/or cholecystokinin provide useful therapeutic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.