Mammalian primate erythrocyte bound heteropolymerized monoclonal antibodies and methods of use thereof

US5487890A · kind A · utility

Assignee

• University of Virginia Patent Foundation · US

Inventors

• Ronald P. Taylor · Charlottesville, US
• William M. Sutherland · Earlysville, US
• Craig Reist · Hillsborough, US
• Eleanor L. Wright · Earlysville, US
• Donna J. Webb · Charlottesville, US
• Ronald Labuguen · Charlottesville, US

Key dates

• Filing date: Jan 24, 1994
• Grant date: Jan 30, 1996
• Expiry date: Jan 24, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Mammalian red blood cells are used to safely and rapidly neutralize and/or clear antigens or immunogens from the circulatory system by binding to the RBC a monoclonal antibody specific for a receptor (CR1) on the RBC, which monoclonal antibody is chemically bound to a second Mab specific for the antigen to be cleared from the circulatory system. These chemically cross-linked monoclonal antibody heteropolymers may be injected directly into the patient's circulatory system. Alternatively, red blood cells, extracted from the patient or provided by a suitable donor, are bound to the Mab complex and returned to the system.