Method for forming controlled release polymeric substrate
US5487895A · kind A · utility
106Cited by
29References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 13, 1993 |
| Grant date | Jan 30, 1996 |
| Priority date | — |
| Expiry date | Aug 13, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5052
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for forming a controlled release polymeric substrate is provided by contacting a polymeric substrate with a liquid mixture containing a cross-linking agent at least partially soluble therein comprising water and an organic liquid, for a period of time and at a temperature and concentration of the agent sufficient for the agent to penetrate the substrate to form cross-linking bridges in the substrate in a decreasing concentration gradient beneath the surface.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.