Syringe assembly and method for lyophilizing and reconstituting injectable medication
US5489266A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 25, 1994 |
| Grant date | Feb 6, 1996 |
| Priority date | — |
| Expiry date | Jan 25, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2005/3121
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A syringe assembly includes a substantially cylindrical syringe barrel and a plunger assembly. The plunger assembly includes a distally disposed flow channelizer and a proximally disposed stopper releasably engaged with one another. The stopper includes an aperture engageable with the distal end of a plunger rod. The flow channelizer includes flutes for accommodating an outflow of vapor during lyophilization and to enable efficient mixing of a lyophilized medication and a diluent. Liquid medication in the syringe chamber is lyophilized and a vacuum is applied to the syringe barrel. The plunger assembly then is urged distally into sealing engagement with the syringe barrel. A plunger rod is engaged with the stopper, and is moved proximally to simultaneously separate the stopper from the flow channelizer and to draw diluent into the chamber for reconstituting the previously lyophilized medication.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.