DNA coding for growth-inhibitory factor and use thereof
US5489514A · kind A · utility
1Cited by
2References
10Claims
0Family size
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Key dates
| Filing date | Aug 28, 1992 |
| Grant date | Feb 6, 1996 |
| Priority date | — |
| Expiry date | Aug 28, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A novel protein of GIF having growth-inhibitory action, which is present in the brain of normal subjects but absent in the brain of patients with Alzheimer disease, was cloned from a human-cerebral cDNA library and human genomic DNA library. Further, Escherichia coli was transformed with a vector integrated by the cDNA to express GIF. The DNA coding for the cloned GIF can be used in the genetic diagnosis and gene therapy for Alzheimer disease, and the expression of the DNA in the transformant can bring about a large production of GIF.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.