Methods for blocking the expression of specifically targeted genes
US5491133A · kind A · utility
315Cited by
0References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 19, 1991 |
| Grant date | Feb 13, 1996 |
| Priority date | — |
| Expiry date | Mar 19, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.