Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent
US5492688A · kind A · utility
76Cited by
4References
7Claims
0Family size
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Key dates
| Filing date | Mar 23, 1994 |
| Grant date | Feb 20, 1996 |
| Priority date | — |
| Expiry date | Mar 23, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Metered dose inhaler (MDI) formulations which utilize 1,1,1,2-tetrafluoroethane (HFC 134a) as the sole propellant are made practical by including a polar surfactant such as polyethylene glycol, diethylene glycol monoethyl ether, polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan monooleate, propoxylated polyethylene glycol, and polyoxyethylene (4) lauryl ether for suspending, solubilizing, wetting and emulsifying the drug constituent and lubricating the valve components of the MDI.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.