Method of treating endotoxin effects with 2-methylthio-ATP and analogs
US5492898A · kind A · utility
9Cited by
2References
3Claims
0Family size
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Key dates
| Filing date | Oct 15, 1993 |
| Grant date | Feb 20, 1996 |
| Priority date | — |
| Expiry date | Oct 15, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/44
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of treating mammals to reduce the deleterious effects of endotoxin and endotoxic shock mediators comprising administering a therapeutic amount of a 2-alkylthio-adenosine-5'-nucleotide. The preferred compound is 2-methylthio-adenosine-5'-triphosphate. The nucleotide used in this treatment inhibits lipopolysaccharide-induced GTPase activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.