Bimodal molecular weight hyaluronate formulations and methods for using same
US5492936A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 23, 1992 |
| Grant date | Feb 20, 1996 |
| Priority date | — |
| Expiry date | Oct 23, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/728
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods useful for protecting human or animal eye cell layers and tissues exposed to trauma, e.g., during surgery, are disclosed. In one embodiment, the method comprises administering a protective amount of an ophthalmically acceptable aqueous composition containing a first alkali metal and/or alkaline earth metal hyaluronate fraction having a molecular weight of at least about 2 million, for example, in the range of about 2 million to about 4 million, and a second alkali metal and/or alkaline earth metal hyaluronate fraction having a molecular weight of about 200,000 to about 800,000, for example, in the range of about 300,000 to 700,000, to eye cell layers and tissues prior to the exposure to the trauma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.