Process for synthesizing carbapenem intermediates using a rhodium catalyst and lewis acid
US5493018A · kind A · utility
3Cited by
9References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 25, 1994 |
| Grant date | Feb 20, 1996 |
| Priority date | — |
| Expiry date | Jan 25, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to the synthesis of a bicyclic ketoester compound of the formula 1 obtained by cyclizing a diazo compound of formula 2: in the presence of a rhodium catalyst. ##STR1## By adding an effective amount of a Lewis acid to the cyclization reaction, the reaction selectively produces the 1-beta methyl isomer, and epimerization of the 1-beta methyl compound to the 1-alpha isomer is minimized.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.