5-substituted derivatives of mycophenolic acid

US5493030A · kind A · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• David J. Morgans, Jr. · Los Altos, US
• David B. Smith · San Bruno, US
• Francisco Xavier Talamas · Livingston, US
• Dean R. Artis · Kensington, US
• Alicia Cervantes · Mexico City, MX
• Todd Richard Elworthy · Palo Alto, US
• Mario Fernandez · Cuernavaca, MX
• Fidencio Franco · Naucalpan, MX
• Ronald Charles Hawley · Oakland, US
• Teresa Lara · Toluca, MX
• David Garrett Loughhead · Belmont, US
• Peter H. Nelson · Los Altos, US
• John W. Patterson · Maple Valley, US
• John C. Rohloff · Palo Alto, US
• Eric Brian Sjogren · Mountain View, US
• Alejandra Trejo · Palo Alto, US
• Ann M. Waltos · San Ramon, US
• Robert James Weikert · Clifton, US

Key dates

• Filing date: Feb 18, 1994
• Grant date: Feb 20, 1996
• Expiry date: Feb 18, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65517
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The disclosed hexenoic acid side-chain derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil, including immune, inflammatory, tumor, proliferative, viral or psoriatic disorders.