Apparatus and methodology for determining oxygen in biological systems
US5494030A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 12, 1993 |
| Grant date | Feb 27, 1996 |
| Priority date | — |
| Expiry date | Aug 12, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/281
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The invention provides apparatus and methods for measuring oxygen tensions in biological systems utilizing physiologically acceptable paramagnetic material, such as India ink or carbon black, and electron paramagnetic resonance (EPR) oximetry. India ink is introduced to the biological system and exposed to a magnetic field and an electromagnetic field in the 1-2 GHz range. The EPR spectra is then measured at the biological system to determine oxygen concentration. The EPR spectra is determined by an EPR spectrometer that adjusts the resonator to a single resonator frequency to compensate for movements of the biological system, such as a human or animal. The biological system can also include other in vivo tissues, cells, and cell cultures to directly measure pO.sub.2 non-destructively.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.