Multicyclic tertiary amine polyaromatic squalene syntase inhibitors
US5494918A · kind A · utility
22Cited by
7References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 7, 1994 |
| Grant date | Feb 27, 1996 |
| Priority date | — |
| Expiry date | Oct 7, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to polycyclic compounds containing two mono- and/or bicyclic rings and a basic tertiary amino group capable of forming an ammonium ion at biological pH and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.