Modification of protein by use of a controllable interveining protein sequence
US5496714A · kind A · utility
81Cited by
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36Claims
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Assignee
Inventors
Key dates
| Filing date | Dec 9, 1992 |
| Grant date | Mar 5, 1996 |
| Priority date | — |
| Expiry date | Dec 9, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/92
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to modified proteins and methods of their production. The modified proteins comprise a controllable intervening protein sequence (CIVPS) inserted into a target protein, the CIVPS being capable of excision from the modified protein under predetermined conditions, i.e., increase in temperature, exposure to light, unblocking of amino acid residues by dephosphorylation or deglycosylation. If desired, the modified protein can be subjected to these conditions. The CIVPS may also be inserted into a region that substantially inactivates target protein activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.