Broad-spectrum tumor suppressor genes, gene products and methods for tumor suppressor gene therapy
US5496731A · kind A · utility
Inventors
Key dates
| Filing date | Mar 25, 1993 |
| Grant date | Mar 5, 1996 |
| Priority date | — |
| Expiry date | Mar 25, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a broad-spectrum tumor suppressor gene and the protein expressed by that gene in appropriate host cells. The protein is a second in-frame AUG codon-initiated retinoblasoma protein of about 94 kD relative molecular mass. The present invention also relates to methods of treating a mammal having a disease or disorder characterized by abnormal cellular proliferation, such as a tumor or cancer and methods of treating abnormally proliferating cells, such as tumor or cancer cells. Treatment is accomplished by inserting a host cell compatible p94.sup.RB expression vector or an effective amount of p94.sup.RB protein into a cell or cells in need of treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.