Process for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia in vertebrates

US5496803A · kind A · utility

Assignee

• Louisiana State University Agricultural and Mechanical College · US

Inventors

• Albert H. Meier · Baton Rouge, US
• Anthony H. Cincotta · Baton Rouge, US

Key dates

• Filing date: Aug 8, 1994
• Grant date: Mar 5, 1996
• Expiry date: Aug 8, 2014

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for the long-term modification and regulation of lipid metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia (the three hallmarks of Type II diabetes)--by injections into the bloodstream of a vertebrate, animal or human, of prolactin, or both prolactin and a glucocorticosteroid. The injections are made over a limited period at a time of day dependent on the normal circadian rhythm of fat and lean members of a similar species. Decreases (or increases) in body fat deposits result by treatment of an obese species (lean species) on a daily timed sequence based on circadian rhythms of the peak prolactin, or peak prolactin and peak glucocorticosteroid, blood level established for lean members (or obese members) of a similar species. Insulin resistance, and hyperinsulinemia can also be controlled in humans on a long-term basis by treatment corresponding to that of the treatment for obesity. The short-term daily injections reset hormonal timing in the neural centers of the brain to produce long-term effects.