Metallocenes as anti-tumor drugs
US5496854A · kind A · utility
Assignees
Inventor
Key dates
| Filing date | Feb 17, 1995 |
| Grant date | Mar 5, 1996 |
| Priority date | — |
| Expiry date | Feb 17, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F17/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel titanocene derivatives possessing chemotherapeutic activity and method for their preparation. These compounds possess two cyclopentadiene rings linked to titanium as a central atom and bound covalently to two phenoxy groups which possess a substituent R selected from the group consisting of COOCH.sub.3, COOC.sub.2 H.sub.5, H, COOCH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 and are free from amino, nitro, chloride and fluoride groups. The novel compounds represent a compromise between the main properties for an antitumor agent, i.e., electrophilicity and stability, being water soluble. Cytotoxicity measurements of these compounds showed significant growth inhibition properties, expressed in terms of IC.sub.50 [M] values.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.