Nitroglycerine plaster and process for its production

US5498418A · kind A · utility

Assignees

• Schwarz Pharma Ltd. · DE
• LTS Lohmann Therapie-Systeme GmbH Co. KG · DE

Inventors

• Dieter Beutner · Monheim, DE
• Henning von Knobelsdorff · Bonn, DE
• Hans-Michael Wolff · Monheim, DE
• Rainer Hoffmann · Langenfeld, DE
• Reinhold Meconi · Neuwied, DE
• Robert-Peter Klein · Neuwied, DE

Key dates

• Filing date: Mar 14, 1994
• Grant date: Mar 12, 1996
• Expiry date: Mar 14, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a dermal plaster for the transdermal provision of nitroglycerin comprising a carrier film and a removable protective film and an adhesive mass containing nitroglycerine on the basis of a cross-linked acrylate-vinyl acetate copolymer in which the monomer mix used for polymerization consists essentially of 21 to 40% wt. vinyl acetate, 55 to 70% wt. of an acrylic acid C2-8 alkyl ester and 3 to 10% wt. of an acrylic acid C2-4 hydroxyalkyl ester and which is cross-linked by heating and the removal of any solvents present after the addition of a cross-linking agent and the nitroglycerin.