Acylaminoindole derivatives as 5-ht1 agonists

US5498626A · kind A · utility

Assignee

• PFIZER INC. · US

Inventor

• John E. Macor · Guilford, US

Key dates

• Filing date: Sep 14, 1994
• Grant date: Mar 12, 1996
• Expiry date: Sep 14, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

##STR1## Compounds of formula (I) where n is 0, 1, or 2; m is 0 or 1; Y and W are each an amino acid residue; R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, aryl, C.sub.1 -C.sub.3 alkylaryl, or C.sub.1 -C.sub.3 alkylheteroaryl, and --(CH.sub.2).sub.p R.sub.3 ; R.sub.2 is CF.sub.3, C.sub.1 -C.sub.6 alkyl, aryl, C.sub.1 -C.sub.3 alkylaryl, and --OR.sub.5 ; R.sub.3 is cyano, trifluoromethyl, or --OR.sub.4 ; R.sub.4 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.3 alkylaryl, or aryl; R.sub.5 is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.3 alkylaryl, or aryl; R.sub.6 is hydrogen, --OR.sub.7, or --NHCOR.sub.7 ; R.sub.7 is hydrogen, C.sub.1 to C.sub.6 alkyl, aryl or C.sub.1 to C.sub.3 alkyl-aryl; p is 1, 2, or 3; and the above aryl groups and the aryl moieties of the above alkyl-aryl groups are independently selected from phenyl and substituted phenyl, wherein said substituted phenyl may be substituted with one to three groups selected from C.sub.1 to C.sub.4 alkyl, halogen, hydroxy, cyano, carboxamide, nitro, and C.sub.1 to C.sub.4 alkoxy and the pharmaceutically acceptable salts thereof. These compounds are useful in treating migraine a…