Sterol regulatory element binding proteins and their use in screening assays
US5498696A · kind A · utility
5Cited by
3References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 13, 1993 |
| Grant date | Mar 12, 1996 |
| Priority date | — |
| Expiry date | May 13, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4702
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A nuclear protein which binds sterol regulatory elements (SREs), such as SRE-1 of the low density lipoprotein (LDL) receptor gene, and mediates sterol-regulated transcription of the LDL receptor gene is disclosed. Also described are screening assay and methods for the identification of agents capable of promoting LDL receptor gene transcription for use in reducing plasma cholesterol and treating the various medical problems associated therewith.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.