Preparation of benzindole compounds from naphthalene compounds
US5498727A · kind A · utility
2Cited by
8References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 19, 1994 |
| Grant date | Mar 12, 1996 |
| Priority date | — |
| Expiry date | Jul 19, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/90
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a process for preparing a substituted 2-amino-benz[cd]indole of the Formula I: ##STR1## The nitro group of a substituted 1-nitro-8-cyano-naphthalene compound is reduced to an amine group to form a substituted 1-amino-8-cyano-naphthalene compound, which is cyclized to form the substituted 2-amino-benz[cd]indole. The reduction and cyclization may be effected in a one-pot procedure using a reducing agent such as stannous chloride, which generates an acid that cyclizes the reduction product. The syntheses of the 1-nitro-8-cyanonaphthalene compound and its precursors are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.