Process for the preparation of 1-fluoro-cyclopropane-1-carboxylic acid

US5498750A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Stefan Bohm · Cologne, DE
• Albrecht Marhold · Leverkusen, DE

Key dates

• Filing date: Mar 15, 1995
• Grant date: Mar 12, 1996
• Expiry date: Mar 15, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C67/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A new process for the preparation of 1-fluoro-cyclopropane-1-carboxylic acid of the formula ##STR1## which process comprises a) reacting in a first step, a 1-fluoro-cyclopropyl phenyl ketone of the formula ##STR2## in which R represents hydrogen, halogen, methyl, methoxy, phenyl or phenoxy, with an peroxy compound in the presence of a diluent, and PA1 b) reacting, in a second step, the resulting 1-fluoro-cyclopropane-1-carboxylate of the formula ##STR3## in which R has the abovementioned meaning, with a base in the presence of a diluent, and then acidifying the mixture. New 1-fluoro-cyclopropane-1-carboxylates of the above-mentioned formula.