Method for preparing cephalosporin derivatives
US5498787A · kind A · utility
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17Claims
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Key dates
| Filing date | Apr 20, 1994 |
| Grant date | Mar 12, 1996 |
| Priority date | — |
| Expiry date | Apr 20, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for preparing cephalosporm derivatives by reacting cephalosporin alkaline metal salts with organic halide in the presence of quaternary ammonium salts catalyst is disclosed. .DELTA..sup.3 .fwdarw..DELTA..sup.2 isomerization, a side reaction commonly reported in preparation of cephalosporin derivatives was successfully eliminated. The desired .DELTA..sup.3 was obtained as a sole product in the reaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.