Inhibition of IL-2 production by Tripterygium wilfordii Hook F extract
US5500340A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 14, 1993 |
| Grant date | Mar 19, 1996 |
| Priority date | — |
| Expiry date | Oct 14, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K36/37
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention involves the use of Tripterygium Wilfordii Hook F extracts in the treatment of rheumatoid arthritis. An alcohol extract of this plant (T2) inhibited antigen- and mitogen-stimulated proliferation of T cells and B cells, cell cycle progression, interleukin-2 (IL-2) production by T cells, immunoglobulin production by B cells and interleukin-2 mRNA production. T2 did not affect IL-2 receptor expression by T cells, IL-1 production by monocytes, the capacity of monocytes to present antigen, or signaling pathways. Inhibition could not be accounted for by nonspecific toxicity. These results support the conclusion that T2 exerts a powerful suppressive effect on human immune responses. Suppressing autoimmune disease is a most preferred embodiment of this invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.