Derivatives of peptides usable as inhibitors of bacterial collagenases
US5500414A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 22, 1994 |
| Grant date | Mar 19, 1996 |
| Priority date | — |
| Expiry date | Jun 22, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel peptide derivatives usable as inhibitors of bacterial collagenases. These derivatives comply with the formula: ##STR1## in which R.sup.1 is a hydrogen atom, a blocking group or a radical derived from an amino acid or a peptide optionally protected by a blocking group, R.sup.2 is the side chain of an .alpha.-amino acid, R.sup.3 is H, a metal, an alkyl or benzyl group, R.sup.4 is the derivative of proline, hydroxyproline, thiazolidine or dehydroproline, R.sup.5 is H or an alkyl, R.sup.6 is the side of an amino acid and R.sup.7 is OR.sup.8 with R.sup.8 being H, a metal, alkyl or benzyl, or in which R.sup.1 and R.sup.7 together form a divalent radical derived from an amino acid or a peptide. The derivatives in which R.sup.3 is a metal or hydrogen are usable as inhibitors of bacterial collagenases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.