Assay of free and complexed prostate-specific antigen
US5501983A · kind A · utility
31Cited by
1References
20Claims
0Family size
Inventors
Key dates
| Filing date | Mar 19, 1993 |
| Grant date | Mar 26, 1996 |
| Priority date | — |
| Expiry date | Mar 19, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/57438
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
According to the method of the invention, immunoassays are applied to measure free PSA as well as a proteinase inhibitor complex. Free PSA and PSA complex are according to the invention measured by a non-competitive immunoassay employing at least two different antibodies. The invention is further characterized in that the PSA proteinase inhibitor complex of interest is formed with .alpha..sub.1 -antichymotrypsin. Moreover, the invention is characterized in that free PSA, the PSA-proteinase inhibitor complex and their ratio are applied in the diagnosis of patients with prostate cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.