11.beta.-substituted 14,17-ethanoestratrienes, process for their production and their use as pharmaceutical agents

US5502046A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Rolf Bohlmann · Berlin, DE
• Hermann Kunzer · Hermeskeil, DE
• Hans-Peter Muhn-Seipoldy · Berlin, DE
• Yukishige Nishino · Berlin, DE
• Martin Schneider · Remchingen, DE

Key dates

• Filing date: Jun 24, 1994
• Grant date: Mar 26, 1996
• Expiry date: Jun 24, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 11 .beta.-substituted 14,17-ethanoestratrienes of the general formula 1 ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are defined in the specification. The compound have antiestrogenic activity and are, therefore, useful for the treatment of estrogen dependent disorders.