3-aminopyrroles, methods for their synthesis and for their pharmaceutical use

US5502051A · kind A · utility

Assignee

• Arzneimittelwerk Dresden GmbH · DE

Inventors

• Peter Scharfenberg · Wuppertal, DE
• Ju/ rgen Liebscher · Berlin, DE
• Alexander Knoll · Berlin, DE
• Aleksej Uschmajew · Berlin, DE
• Andreas Rolfs · Berlin, DE
• Dieter Lohman · Radebeul, DE
• Gottfried Faust · Berlin, DE
• Eveline Morgenstern · Berlin, DE

Key dates

• Filing date: Nov 16, 1990
• Grant date: Mar 26, 1996
• Expiry date: Nov 16, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to 3-aminopyrroles of formula I, which are largely new, to methods for the preparation and to their use as medicinal agents and preparations, as well as to anti-convulsive or analgesic preparations containing these 3-aminopyrroles. Disubstituted and monosubstituted amino groups are claimed as 3-amino substituents. The invention pursues the objective of developing largely new 3-aminopyrroles, which have CNS activity, particularly ones which anti-convulsive or analgesic properties, as well as methods for their preparation and their use as medicinal preparations. Pursuant to the invention, the synthesis is carried out by cyclizing open-chain precursors, such as aminoacrylic acid derivative, or by modifying pyrroles.